Stevens-Johnson综合征的治疗及预后：38例回顾性分析

目的 探讨药物诱发性Stevens-Johnson综合征的治疗及预后。方法 回顾性分析38例药物诱发性Stevens-Johnson综合征住院患者的临床和实验室资料、治疗及预后。结果 前三类致病药物包括抗生素、非甾体抗炎药和卡马西平。29例静脉应用糖皮质激素（甲泼尼龙）治疗,9例静脉用免疫球蛋白和糖皮质激素联合治疗。联合治疗组的平均起始日激素剂量、出院时日激素剂量、累积激素剂量（均为泼尼松相当量）均明显低于糖皮质激素组（P=0.001,0.001和0.025）。38例患者均治愈。单用激素组中,2例继发口腔真菌感染,1例合并急性胰腺炎,1例并发慢性角膜炎; 联合治疗组未观察到不良反应或并发症。结...

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Published in中国皮肤性病学杂志 Vol. 30; no. 8; pp. 796 - 798
Main Author 陈娜娜 张立明 肖汀
Format Journal Article
LanguageChinese
Published 2016
Subjects
Stevens-Johnson综合征
免疫球蛋白
皮质激素
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Summary:目的 探讨药物诱发性Stevens-Johnson综合征的治疗及预后。方法 回顾性分析38例药物诱发性Stevens-Johnson综合征住院患者的临床和实验室资料、治疗及预后。结果 前三类致病药物包括抗生素、非甾体抗炎药和卡马西平。29例静脉应用糖皮质激素（甲泼尼龙）治疗,9例静脉用免疫球蛋白和糖皮质激素联合治疗。联合治疗组的平均起始日激素剂量、出院时日激素剂量、累积激素剂量（均为泼尼松相当量）均明显低于糖皮质激素组（P=0.001,0.001和0.025）。38例患者均治愈。单用激素组中,2例继发口腔真菌感染,1例合并急性胰腺炎,1例并发慢性角膜炎; 联合治疗组未观察到不良反应或并发症。结论 糖皮质激素疗法和免疫球蛋白-皮质激素联合疗法治疗Stevens-Johnson综合征均有效,并且联合疗法糖皮质激素用量明显减少。
Bibliography:Stevens-Johnson syndrome ; Corticosteroid ; Intravenous immunoglobulin （IVIG）
Objective To analyze the treatment and prognosis of drug-induced Stevens-Johnson syndrome（SJS）. Methods This retrospective study enrolled 38 inpatients with drug-induced SJS. Clinical and laboratory data, treatment and prognosis of the patients were recorded. Results The most common offending drugs included antibiotics, non-steroidal anti-inflammatory drugs and carbamazepine. Twenty-nine patients administered intravenous corticosteroid（methylprednisolone）therapy（CS group）, while 9 patients received intravenous immunoglobulin（IVIG）-corticosteroid combination therapy（IVIG-CS group）. Compared with CS group, IVIG-CS group showed significantly lower starting daily prednisone equivalent dose（P=0.001）, daily prednisone equivalent dose at discharge（P=0.001）and cumulative prednisone equivalent dosage（P=0.025）. All the 38 patients were cured. In CS group, 2 cases suffered from thrush, 1 suffered from acute pancreatitis and another 1 suffered f
ISSN:1001-7089