Palcernuine, the first [5/6/6/6]-cernuane-type alkaloid from Palhinhaea cernua f.sikkimensis

One novel（named palcernuine, 1） and five known cernuane-type（2–6） alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectro...

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Published in中国化学快报：英文版 no. 6; pp. 969 - 973
Main Author Yu Tang Juan Xiong Yike Zou Bastien Nay Li-Jun Wang Jin-Feng Hu
Format Journal Article
LanguageEnglish
Published 2016
Subjects
ne型
圆二色谱
氮原子
生物合成途径
生物碱
绝对构型
计算结果
谱方法
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Summary:One novel（named palcernuine, 1） and five known cernuane-type（2–6） alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism（ECD） spectra. A plausible biosynthetic pathway to 1 is proposed.
Bibliography:11-2710/O6
Palhinhaea cernua f.sikkimensis; Lycopodiaceae; Palcernuine; Cernuane-type alkaloids; Biosynthetic pathway
One novel（named palcernuine, 1） and five known cernuane-type（2–6） alkaloids were isolated from the whole plant of Palhinhaea cernua f. sikkimensis. The structure of 1, possessing an unprecedented [5/6/6/6]-tetracyclic ring system containing two nitrogen atoms, was established on the basis of spectroscopic methods, and its absolute configuration was determined by comparison of the experimental and calculated electronic circular dichroism（ECD） spectra. A plausible biosynthetic pathway to 1 is proposed.
ISSN:1001-8417
1878-5964