Copper-Catalyzed Redox-Triggered Remote C--H Functionali- zation： Highly Selective Formation of C--CF3 and C--O Bonds

A Cu-catalyzed remote sp3 C--H/unactivated alkenes functionalization reaction for the concomitant construc- tion of C--CF3 and C--O bonds was described. An 1,5-H radical transfer involving an sp3 C--H bond adjacent to a nitrogen atom and an a-CF3-alkyl radical intermediate derived from unactivated a...

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Published in中国化学：英文版 no. 5; pp. 490 - 494
Main Author Taotao Li Peng Yu Jin-Shun Lin Yonggang Zhi Xin-Yuan Liu
Format Journal Article
LanguageEnglish
Published 2016
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Summary:A Cu-catalyzed remote sp3 C--H/unactivated alkenes functionalization reaction for the concomitant construc- tion of C--CF3 and C--O bonds was described. An 1,5-H radical transfer involving an sp3 C--H bond adjacent to a nitrogen atom and an a-CF3-alkyl radical intermediate derived from unactivated alkenes was observed and demon- strated to proceed via the radical process.
Bibliography:A Cu-catalyzed remote sp3 C--H/unactivated alkenes functionalization reaction for the concomitant construc- tion of C--CF3 and C--O bonds was described. An 1,5-H radical transfer involving an sp3 C--H bond adjacent to a nitrogen atom and an a-CF3-alkyl radical intermediate derived from unactivated alkenes was observed and demon- strated to proceed via the radical process.
alkenes, radical trifluoromethylation, 1,5-H radical transfer, Togni＇s reagent
31-1547/O6
ISSN:1001-604X
1614-7065