儿童先天性心脏病血清Apelin水平与肺动脉压关系的初步探讨

目的初步探讨先天性心脏病患儿血清Apelin水平与肺动脉压的关系。方法手术治疗的先心病患儿126例,检测患儿术前及术后第7天的血清Apelin水平。建立体外循环前检测并计算肺动脉收缩压/体循环收缩压（Pp/Ps）的比值,依据Pp/Ps分组：无肺动脉高组压（PAH）组、轻度PAH组、中度PAH组和重度PAH组;术后第7天超声心动图估测肺动脉平均压（PAMP）。结果无PAH,以及轻、中、重度PAH各组术前及术后的血清Apelin水平依次降低,差异有统计学意义（P〈0.05）;术后第7天各组血清Apelin水平较术前均升高,差异有统计学意义（P〈0.05）。术前及术后第7天的血清Apelin水平与肺...

Full description

Saved in:
Bibliographic Details
Published in中国当代儿科杂志 Vol. 18; no. 4; pp. 340 - 344
Main Author 马超 沈定荣 张青 丁以群 王元祥 彭乐 孟保英 提运幸
Format Journal Article
LanguageChinese
Published 2016
Subjects
Apelin
儿童
先天性心脏病
肺动脉高压
Online AccessGet full text

Cover

More Information
Summary:目的初步探讨先天性心脏病患儿血清Apelin水平与肺动脉压的关系。方法手术治疗的先心病患儿126例,检测患儿术前及术后第7天的血清Apelin水平。建立体外循环前检测并计算肺动脉收缩压/体循环收缩压（Pp/Ps）的比值,依据Pp/Ps分组：无肺动脉高组压（PAH）组、轻度PAH组、中度PAH组和重度PAH组;术后第7天超声心动图估测肺动脉平均压（PAMP）。结果无PAH,以及轻、中、重度PAH各组术前及术后的血清Apelin水平依次降低,差异有统计学意义（P〈0.05）;术后第7天各组血清Apelin水平较术前均升高,差异有统计学意义（P〈0.05）。术前及术后第7天的血清Apelin水平与肺动脉压均呈负相关（r=-0.51,-0.54,P〈0.05）。结论先心病患儿并发肺动脉高压及其发展与血清Apelin水平降低有关系,血清Apelin对诊断先心病患儿是否并发肺动脉高压及其程度的意义值得深入研究。
Bibliography:ObjectiveTo preliminarily investigate the relationship between serum apelin level and pulmonary artery pressure in children with congenital heart disease.MethodsOne hundred and twenty-six children with congenital heart disease undergoing surgical treatment were enrolled as subjects. The serum level of apelin was determined before surgery and at 7 days after surgery. The ratio of pulmonary artery systolic pressure to aortic systolic pressure （Pp/Ps） was calculated before extracorporeal circulation. According to the Pp/Ps value, patients were classiifed into non-pulmonary arterial hypertension （PAH） group, mild PAH group, moderate PAH group, and severe PAH group. Pulmonary artery mean pressure was estimated by echocardiography at 7 days after surgery.ResultsThe non-PAH group had the highest serum level of apelin before and after surgery, followed by the mild PAH group, moderate PAH group, and severe PAH group （P〈0.05）. All groups had signiifcantly increased serum levels of apelin at 7 days after surgery （P〈0.05
ISSN:1008-8830