Benzoic Acid： an Efficient and Rapid Catalyst for the Synthesis of a-Hydroxyl（indolyl）ethanones from Indoles

An efficient method for regioselective Friedel-Crafts alkylations of indole using arylglyoxals in the presence of benzoic acid has been discovered. The reactions proceeded smoothly at room temperature under metalfree conditions and generated the corresponding products in good to excellent yields. Th...

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Bibliographic Details
Published in高等学校化学研究：英文版 no. 2; pp. 212 - 218
Main Author LV Guanghui CHENG Xu ZHENG Yang LI Weijian HAI Li WU Yong
Format Journal Article
LanguageEnglish
Published 2016
Subjects
乙二醛
催化剂
反应
吲哚
吸引力
对羟基苯甲酸
烷基化
羟基合成
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Summary:An efficient method for regioselective Friedel-Crafts alkylations of indole using arylglyoxals in the presence of benzoic acid has been discovered. The reactions proceeded smoothly at room temperature under metalfree conditions and generated the corresponding products in good to excellent yields. This methodology has a broad substrate scope and opens up an interesting and attractive avenue for the synthesis of a-hydroxyl（indolyl）- ethanones.
Bibliography:Friedel-Crafts alkylation; Indole; Arylglyoxal; Benzoic acid
22-1183/O6
An efficient method for regioselective Friedel-Crafts alkylations of indole using arylglyoxals in the presence of benzoic acid has been discovered. The reactions proceeded smoothly at room temperature under metalfree conditions and generated the corresponding products in good to excellent yields. This methodology has a broad substrate scope and opens up an interesting and attractive avenue for the synthesis of a-hydroxyl（indolyl）- ethanones.
ISSN:1005-9040
2210-3171