强光疗治疗新生儿高胆红素血症的疗效及安全性

目的探讨采用强光疗治疗新生儿高胆红素血症的疗效及安全性。方法对144例新生儿高胆红素血症患儿进行前瞻性随机分组,其中强光疗组和传统光疗组各72例,对两组疗效及并发症等情况进行比较。结果光疗后12h内强光疗组患儿血总胆红素水平明显低于传统光疗组（P〈0.05）,且胆红素下降幅度明显高于传统光疗组（P〈0.05）。强光疗组患儿总光疗时间明显短于传统光疗组（P〈0.05）。两组患儿光疗后发热、腹泻、皮疹、低钙血症发生率及光疗后血钙水平和血红蛋白下降水平等比较差异均无统计学意义。结论强光疗在光疗开始初期可迅速有效降低高胆红素血症患儿血中胆红素水平,缩短总光疗时间,且不增加不良反应的发生率,是一种优于传...

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Published in中国当代儿科杂志 Vol. 18; no. 3; pp. 195 - 200
Main Author 张晓蕊 曾超美 刘捷
Format Journal Article
LanguageChinese
Published 2016
Subjects
光照疗法
强光疗
新生儿
高胆红素血症
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Summary:目的探讨采用强光疗治疗新生儿高胆红素血症的疗效及安全性。方法对144例新生儿高胆红素血症患儿进行前瞻性随机分组,其中强光疗组和传统光疗组各72例,对两组疗效及并发症等情况进行比较。结果光疗后12h内强光疗组患儿血总胆红素水平明显低于传统光疗组（P〈0.05）,且胆红素下降幅度明显高于传统光疗组（P〈0.05）。强光疗组患儿总光疗时间明显短于传统光疗组（P〈0.05）。两组患儿光疗后发热、腹泻、皮疹、低钙血症发生率及光疗后血钙水平和血红蛋白下降水平等比较差异均无统计学意义。结论强光疗在光疗开始初期可迅速有效降低高胆红素血症患儿血中胆红素水平,缩短总光疗时间,且不增加不良反应的发生率,是一种优于传统光疗的治疗措施。
Bibliography:ZHANG Xiao-Rui, ZENG Chao-Mei, LIU Jie（Department of Pediatrics, Peking University People＇s Hospital, Beijing 100044, China）
Hyperbilirubinemia; Phototherapy; Intensive phototherapy; Neonate
Objective To study the effect and safety of intensive phototherapy in the treatment of neonatal hyperbilirubinemia. Methods A total of 144 neonates with neonatal hyperbilirubinemia were randomly and prospectively divided into intensive phototherapy group and conventional phototherapy group, with 72 neonates in each group. The therapeutic effect and incidence of complications were compared between the two groups. Results Within 12 hours after phototherapy, the total serum bilirubin level in the intensive phototherapy group was significantly lower than in the conventional phototherapy group（P〈0.05）, and the intensive phototherapy group had a significantly greater reduction in serum bilirubin level than the conventional phototherapy group（P〈0.05）. The intensives phototherapy group had a significantly shorter time of photothera
ISSN:1008-8830