Synthesis of Terphenyl Derivatives by Pd-Catalyzed Suzuki-Miyaura Reaction of Dibromobenzene Using 2N20-Salen as a Ligand in Aqueous Solution

A simple and efficient catalytic system for Na2PdC14 catalyzing the Suzuki-Miyaura reaction of dibromoben- zene and arylboronic acid has been developed by using 2N2O-salen as a ligand in H2O/EtOH （V ： V=4 ： 1） at 100 ℃. Using this method, the reactions of substrates containing sterically demanding o...

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Bibliographic Details
Published in中国化学：英文版 no. 10; pp. 1189 - 1193
Main Author Ningning Gu Yashuai Liu Ping Liu Xiaowei Ma Liu Yan Bin Dai
Format Journal Article
LanguageEnglish
Published 2015
Subjects
Salen
偶联反应
合成
溴苯
联苯衍生物
配体
钯催化
铃木
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Summary:A simple and efficient catalytic system for Na2PdC14 catalyzing the Suzuki-Miyaura reaction of dibromoben- zene and arylboronic acid has been developed by using 2N2O-salen as a ligand in H2O/EtOH （V ： V=4 ： 1） at 100 ℃. Using this method, the reactions of substrates containing sterically demanding ortho substituents （e.g. dibromo- benzene and/or arylboronic acids） proceeded efficiently, with the corresponding terphenyl derivatives being pro- duced in moderate to excellent yields. Furthermore, this method offers interesting features for the multi-gram scale synthesis of terphenyl compound.
Bibliography:terphenyls, synthesis, 2N2O-salen, palladium, catalyze, Suzuki-Miyaura reaction
A simple and efficient catalytic system for Na2PdC14 catalyzing the Suzuki-Miyaura reaction of dibromoben- zene and arylboronic acid has been developed by using 2N2O-salen as a ligand in H2O/EtOH （V ： V=4 ： 1） at 100 ℃. Using this method, the reactions of substrates containing sterically demanding ortho substituents （e.g. dibromo- benzene and/or arylboronic acids） proceeded efficiently, with the corresponding terphenyl derivatives being pro- duced in moderate to excellent yields. Furthermore, this method offers interesting features for the multi-gram scale synthesis of terphenyl compound.
31-1547/O6
ISSN:1001-604X
1614-7065