Recent Advances in Microbial Degradation of 4-hydroxy- benzoate-a Review

4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： protocatechuate cleavage pathway; catechol cleavage pathway; anaerobic degradation pathw...

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Published in农业生物技术：英文版 Vol. 4; no. 4; pp. 52 - 57
Main Author Chaoyan XU Jingjing LI Liping ZHANG Wengjun WANG Ke XING Jun TIAN Zhaozhong FENG Xue PENG
Format Journal Article
LanguageEnglish
Published 2015
Subjects
人工制品
嗜热芽孢杆菌
天然产品
审查
微生物降解
羟基苯甲酸
芳香族化合物
裂解途径
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Summary:4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： protocatechuate cleavage pathway; catechol cleavage pathway; anaerobic degradation pathway in anaerobes ; and gentisate cleavage pathway. The last pathway including a NIH shift reaction remains to be elucidated. In this review we emphasized on the NIH shift reaction involved in the 4HBA degrdation. The key enzymes of each 4HBA metabolic pathway also were introduced. Finnaly, we described the thermophilic Bacillus sp. B1 strain which was capable of degrading varous aromatic compounds including gHBA, and presented a direction for the research of NIH shift reaction.
Bibliography:4-Hydroxybenzoate, NIH shift reaction, Gentisate, Thermophilic Bacillus
4-Hydroxybenzoate （4HBA） is a naturally occurring aromatic compound, as a key intermediate metabolite not only for natural products but also for arti- ficial products. There are four metabolic pathways for 4HBA： protocatechuate cleavage pathway; catechol cleavage pathway; anaerobic degradation pathway in anaerobes ; and gentisate cleavage pathway. The last pathway including a NIH shift reaction remains to be elucidated. In this review we emphasized on the NIH shift reaction involved in the 4HBA degrdation. The key enzymes of each 4HBA metabolic pathway also were introduced. Finnaly, we described the thermophilic Bacillus sp. B1 strain which was capable of degrading varous aromatic compounds including gHBA, and presented a direction for the research of NIH shift reaction.
ISSN:2164-4993