Synthesis and bio-evaluation of phenothiazine derivatives as new antituberculosis agents

Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against Mycobacterium tuberculosis H37RV. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mamma...

Full description

Saved in:
Bibliographic Details
Published in中国化学快报：英文版 no. 8; pp. 951 - 954
Main Author Chun-Xian He Hui Meng Xiang Zhang Hua-Qing Cui Da-Li Yin
Format Journal Article
LanguageEnglish
Published 2015
Subjects
化合物相
吩噻嗪衍生物
哺乳动物
抗结核药物
生物评价
细胞毒性
结核分枝杆菌
药物合成
Online AccessGet full text

Cover

More Information
Summary:Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against Mycobacterium tuberculosis H37RV. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mammalian cell cytotoxicity, compound 6e merits to be further explored as new anti-tuberculosis agents.
Bibliography:11-2710/O6
tuberculosis mother Mycobacterium cytotoxicity dimethylamino likely moiety mammalian alkyl phenoxy
Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against Mycobacterium tuberculosis H37RV. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mammalian cell cytotoxicity, compound 6e merits to be further explored as new anti-tuberculosis agents.
ISSN:1001-8417
1878-5964