Fission yeast telomere-binding protein Tazl is a functiona out not a structural counterpart of human TRF1 and TRF2
Dear Editor, Telomeres, the natural ends of linear eukaryotic chro- mosomes, are essential for cell viability and genome integrity [ 1 ]. In mammalian cells, telomere repeat factors 1 and 2 (TRF1 and TRF2) are the first two identified mammalian telomere-binding proteins that play essential roles in...
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Published in | 细胞研究:英文版 no. 7; pp. 881 - 884 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
2015
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Subjects | |
Online Access | Get full text |
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Summary: | Dear Editor, Telomeres, the natural ends of linear eukaryotic chro- mosomes, are essential for cell viability and genome integrity [ 1 ]. In mammalian cells, telomere repeat factors 1 and 2 (TRF1 and TRF2) are the first two identified mammalian telomere-binding proteins that play essential roles in telomere homeostasis and maintenance [2, 3]. Both TRF1 and TRF2 contain a central TRF homology (TRFH) domain and a C-terminal DNA-binding Myb domain (Supplementary information, Figure S1A) [4]. |
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Bibliography: | 31-1568 Dear Editor, Telomeres, the natural ends of linear eukaryotic chro- mosomes, are essential for cell viability and genome integrity [ 1 ]. In mammalian cells, telomere repeat factors 1 and 2 (TRF1 and TRF2) are the first two identified mammalian telomere-binding proteins that play essential roles in telomere homeostasis and maintenance [2, 3]. Both TRF1 and TRF2 contain a central TRF homology (TRFH) domain and a C-terminal DNA-binding Myb domain (Supplementary information, Figure S1A) [4]. |
ISSN: | 1001-0602 1748-7838 |