Gut microbiota and Ma-Pi 2 macrobiotic diet in thetreatment of type 2 diabetes

In the past 10 years the prevalence of type 2 diabetesmellitus （T2DM） has increased hugely worldwide, driven bya rise in the numbers of overweight and obese individuals.A number of diets have been shown to be effective forthe management of T2DM the Mediterranean diet, thevegetarian diet and the low-...

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Published in世界糖尿病杂志：英文版（电子版） no. 3; pp. 403 - 411
Main Author Francesco Fallucca Lucia Fontana Sara Fallucca Mario Pianesi
Format Journal Article
LanguageEnglish
Published 2015
Subjects
diabetes;Low-grade
diet
Gut
inflammation
Ma-Pi
macrobiotic
Metaboliccontrol
microbiota
Type
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Summary:In the past 10 years the prevalence of type 2 diabetesmellitus （T2DM） has increased hugely worldwide, driven bya rise in the numbers of overweight and obese individuals.A number of diets have been shown to be effective forthe management of T2DM the Mediterranean diet, thevegetarian diet and the low-calorie diet. Results of studiesclearly indicate, however, that the efficacy of these dietsis not solely related to the biochemical structure of theindividual nutrients they contain. This review discussesthis point with reference to the potential role of theintestinal microbiota in diabetes. The macrobiotic Ma-Pi 2diet is rich in carbohydrates, whole grains and vegetables,with no animal fat or protein or added sugar. In shortandmedium-term trials conducted in patients with T2DM,the Ma-Pi 2 diet has been found to significantly improveindicators of metabolic control, including fasting bloodglucose, glycosylated hemoglobin, the serum lipid profile,body mass index, body weight and blood pressure. Thediet may also alter the gut microbiota composition, whichcould additionally affect glycemic control. As a result, theMa-Pi 2 diet could be considered a valid additional shorttomedium-term treatment for T2DM.
ISSN:1948-9358
1948-9358