首次接受5型磷酸二酯酶抑制剂治疗的中国男性勃起功能障碍患者中比较枸橼酸西地那非和他达拉非治疗的开放、多中心、随机交叉研究

Saved in:
Bibliographic Details
Published in亚洲男性学杂志：英文版 no. 1; pp. 61 - 67
Main Author Wen-Jun Bai Hong-Jun Li Yu-Tian Dai Xue-You He Yi-Ran Huang Ji-Hong Liu Sebastian Sorsaburu Chen Ji Jian-Jun Jin Xiao-Feng Wang
Format Journal Article
LanguageEnglish
Published 2015
Subjects
5型磷酸二酯酶抑制剂
勃起功能障碍
患者偏爱
Online AccessGet full text

Cover

More Information
Bibliography:erectile dysfunction; patient preference; phosphodiesterase 5 inhibitors
31-1795/R
The study was to compare treatment preference, efficacy, and tolerability of sildenafil citrate （sildenafil） and tadalafil for treating erectile dysfunction （ED） in Chinese men na＇ive to phosphodiesterase 5 （PDE5） inhibitor therapies. This multicenter, randomized, open-label, crossover study evaluated whether Chinese men with ED preferred 20-mg tadalafil or 100-mg sildenafil. After a 4 weeks baseline assessment, 383 eligible patients were randomized to sequential 20-mg tadalafil per 100-mg sildenafil or vice versa for 8 weeks respectively and then chose which treatment they preferred to take during the 8 weeks extension. Primary efficacy was measured by Question 1 of the PDE5 Inhibitor Treatment Preference Questionnaire （PITPQ）. Secondary efficacy was analyzed by PITPQ Question 2, the International Index of Erectile Function （IIEF） erectile function （EF） domain, sexual encounter profile （SEP） Questions 2 and 3, and the Drug Attributes Questionnaire. Three hundred and fifty men （91%） completed the randomized treatment phase. Two hundred and forty-two per 350 （69.1%） patients preferred 20-mg tadalafil, and 108/350 （30.9%） preferred lO0-mg sildenafil （P 〈 0.001） as their treatment in the 8 weeks extension. Ninety-two per 242 （38%） patients strongly preferred tadalafil and 37/108 （34.3%） strongly the preferred sildenafil. The SEP2 （penetration）, SEP3 （successful intercourse）, and IIEF-EF domain scores were improved in both tadalafil and sildenafil treatment groups. For patients who preferred tadalafil, getting an erection long after taking the medication was the most reported reason for tadalafil preference. The only treatment-emergent adverse event reported by 〉 2% of men was headache. After tadalafil and sildenafil treatments, more Chinese men with ED na＇ive to PDE5 inhibitor preferred tadalafil. Both sildenafil and tadalafil treatments were effective and safe.
ISSN:1008-682X
1745-7262