DNA甲基化在精神分裂症中的作用：研究进展及挑战

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Published in中国科学通报：英文版 no. 2; pp. 149 - 155
Main Author 宗小芬 胡茂林 李宗昌 曹红宝 陈晓岗 唐劲松
Format Journal Article
LanguageEnglish
Published 2015
Subjects
DNA甲基化
候选基因
全基因组
发病机理
环境因素
精神分裂症
精神障碍
遗传修饰
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Bibliography:Schizophrenia is a heterogeneous psychiatric disorder broadly accepted being caused by genetic and environmental factors. Although conventional genetic studies have identified some candidate genes for schizophrenia, low odds ratios and penetrance, and a lack of reproducibility have limited their explanatory power. Despite the major efforts made toward identifying environmental factors in schizophrenia, methodological limitations and inconsistent findings of epidemiological reports have obstructed attempts to identify exogenous causal factors. Epigenetic mechanisms, mediating between environment and genes, have recently been proposed to play an important role in the pathogenesis of schizophrenia. DNA methylation is the most stable and well-characterized epigenetic modification. In this paper, we briefly introduce DNA methylation mechanisms, genome-wide DNA methylation studies, and identify specific genomic methylation sites in individuals diagnosed with schizophrenia. The outline candidate genes such as Reelin and COMT, are also outlined before paying attention to the conundrum of recent researches.
11-1785/N
Schizophrenia ; Epigenetics ; DNA methylation ; Reelin ;Catechol-O-methyltransferase
Xiaofen Zong ,Maolin Hu, Zongchang Li ,Hongbao Cao , Xiaogang Chen , Jinsong Tang（Institute of Mental Health, The Second Xiangya Hospital of Central South University, Changsha 410011, China;Unit on Statistical Genomics, National Institute of Mental Health, NIH, Bethesda 20852, USA;Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha 410011, China;National Technology of Institute of Psychiatry, Central South University, Changsha 410011, China）
ISSN:1001-6538
1861-9541