Recent progress in studies of factors that elicil pancreatic β-cell expansion
The loss of or decreased functional pancreatic β-cell is a major cause of type 1 and type 2 diabetes. Previous studies have shown that adult β-cells can maintain their ability for a low level of turnover through replication and neogenesis. Thus, a strategy to prevent and treat dia- betes would be to...
Saved in:
| Published in | 蛋白质与细胞：英文版 no. 2; pp. 81 - 87 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
2015
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | The loss of or decreased functional pancreatic β-cell is a major cause of type 1 and type 2 diabetes. Previous studies have shown that adult β-cells can maintain their ability for a low level of turnover through replication and neogenesis. Thus, a strategy to prevent and treat dia- betes would be to enhance the ability of β-cells to increase the mass of functionalβ-cells. Consequently, much effort has been devoted to identify factors that can effectively induce β-cell expansion. This review focuses on recent reports on small molecules and protein fac- tors that have been shown to promote β-cell expansion. |
|---|---|
| Bibliography: | pancreatic islet, β-cell, cell proliferation/replication/expansion, cell signaling 11-5886/Q The loss of or decreased functional pancreatic β-cell is a major cause of type 1 and type 2 diabetes. Previous studies have shown that adult β-cells can maintain their ability for a low level of turnover through replication and neogenesis. Thus, a strategy to prevent and treat dia- betes would be to enhance the ability of β-cells to increase the mass of functionalβ-cells. Consequently, much effort has been devoted to identify factors that can effectively induce β-cell expansion. This review focuses on recent reports on small molecules and protein fac- tors that have been shown to promote β-cell expansion. |
| ISSN: | 1674-800X 1674-8018 |