甲状腺癌骨转移的诊疗措施的个例报道及其文献回顾
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| Published in | 浙江大学学报：B卷英文版 Vol. 15; no. 12; pp. 1081 - 1087 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
2014
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| Subjects | |
| Online Access | Get full text |
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| Bibliography: | Thyroid carcinoma, Bone metastasis, Management Differentiated thyroid carcinoma （DTC） is a common malignancy. The general treatments are thyroidec- tomy of the affected lobe along with lymphadenectomy. However, bone metastasis is rare in DTC compared with other malignancies and the management of metastasis loci is still controversial. Here we present a case of follicular thyroid carcinoma with the 6th cervical vertebra body metastasis successfully treated by total thyroidectomy, cervical corpectomy, and intemal fixation, followed by hormone replacement therapy and radioiodine therapy. Eleven additional patients diagnosed as thyroid carcinoma with bone metastasis collected from Chinese literature between January 1996 and December 2013 were also reviewed. The mean age of the 12 patients at presentation was （53.9±9.2） years （rang, 42-72 years） and the male to female ratio was 1：2. Nine cases received total/near-total thyroidectomy or Io- bectomy while the other three patients refused for personal reasons. The interventions for bone metastasis were one-stage operation （9/12）, ITM adjuvant therapy （3/12）, chemotherapy （1/12）, and no intervention （1/12）. During the follow-up, two patients died of metastatic carcinoma recurrence, one died of multiple organ metastasis, and one with an unknown reason. We conclude that the management of thyroid carcinoma with bone metastasis needs multidisci- plinary cooperation. Surgical resection is still the first choice for cure, while the combined one-stage operation on the primary and metastatic sites followed by hormone replacement therapy and radioiodine therapy is an applicable treatment. 33-1356/Q |
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| ISSN: | 1673-1581 1862-1783 |