小肠间质瘤45例诊治分析

目的探讨小肠间质瘤（SIST）的临床特征、诊断及治疗。方法对解放军总医院2007年7月—2013年12月收治的45例SIST患者的临床资料进行回顾性分析,所有病例均经病理证实。结果 SIST的临床表现无特异性,最常见的表现依次为;消化道出血29例（64.4%）,腹痛15例（33.3%）,腹腔肿块4例（8.9%）。SIST常见的好发部位依次为空肠、十二指肠、回肠,分别为21例（46.7%）、13例（28.9%）、9例（20.0%）,另有空回肠交界2例（4.4%）。螺旋CT对SIST的诊断符合率为73.7%（28/38）,在各项检查中最高。外科手术是最重要的治疗方法,45例患者均接受手术治疗,术后...

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Bibliographic Details
Published in解放军医学杂志 Vol. 39; no. 7; pp. 568 - 571
Main Author 曾艳 梁浩
Format Journal Article
LanguageChinese
Published 2014
Subjects
治疗
胃肠道间质肿瘤
诊断
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Summary:目的探讨小肠间质瘤（SIST）的临床特征、诊断及治疗。方法对解放军总医院2007年7月—2013年12月收治的45例SIST患者的临床资料进行回顾性分析,所有病例均经病理证实。结果 SIST的临床表现无特异性,最常见的表现依次为;消化道出血29例（64.4%）,腹痛15例（33.3%）,腹腔肿块4例（8.9%）。SIST常见的好发部位依次为空肠、十二指肠、回肠,分别为21例（46.7%）、13例（28.9%）、9例（20.0%）,另有空回肠交界2例（4.4%）。螺旋CT对SIST的诊断符合率为73.7%（28/38）,在各项检查中最高。外科手术是最重要的治疗方法,45例患者均接受手术治疗,术后病理结果显示：极低度危险6例（13.3%）,低度危险16例（35.6%）,中度危险8例（17.8%）,高度危险15例（33.3%）。术后免疫组化染色CD117阳性率为100%,CD34阳性率为67%（30/45）。甲磺酸伊马替尼对于姑息手术者或预防术后复发有较好疗效。对复发或远处转移者再次手术可延长生存期。结论 SIST临床表现无特异性,早期较难诊断,螺旋CT有较高的诊断价值。当前主要采用外科手术治疗,术后长期服用甲磺酸伊马替尼可取得较好的远期疗效。
Bibliography:gastrointestinal stromal tumors; diagnosis; therapy
ZENG Yan, LIANG Hao （ Department of Gastroenterology, General Hospital of PLA, Beijing 100853, China）
11-1056/R
Objective To study the clinical features, diagnosis and treatment of small intestinal stromal tumor （SIST）. Methods Clinical data of 45 SIST patients admitted to our hospital from July 2007 to December 2013 were analyzed retrospectively. The diagnosis was confirmed pathologically in all the patients. Results The clinical manifestations of SIST were non-specific, and the most common manifestations were as follows： gastrointestinal bleeding in 29 patients （64.4 %）, abdominal pain in 15 （33.3%） and abdominal mass in 4 （8.9%）. The most common predilection sites of SIST were jejunum （n=21, 46.7%）, duodenum （n=13, 28.9%） and ileum （n=9, 20.0%）. The tumor was located at the jejunoileal junction in 2 patients （4.4%）. The diagnostic rate of SIST by spiral CT was 73.7% （28/38）, and it was the most accurate among all the examinations. Surgical operation was the
ISSN:0577-7402