A natural model of behavioral depression in postpartum adult female cynomolgus monkeys （Macaca fascicularis）

Postpartum depression （PPD） is a modified form of major depressive disorders （MDD） that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moder...

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Published in动物学研究 Vol. 35; no. 3; pp. 174 - 181
Main Author Xun-Xun CHU Joshua Dominic Rizak Shang-Chuan YANG Jian-Hong WANG Yuan-Ye MA Xin-Tian HU
Format Journal Article
LanguageChinese
Published 2014
Subjects
交互行为
产后
成年
抑郁症
持续时间
自然模型
雌性
食蟹猴
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Summary:Postpartum depression （PPD） is a modified form of major depressive disorders （MDD） that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moderate symptoms, there exists challenges in exploring and addressing the underlying cause of the depression. This fact highlights the need for relevant animal models. In the present study, postpartum adult female cynomolgus monkeys （Macaca fascicularis） living in breeding groups were observed for typical depressive behavior. The huddle posture behavior was utilized as an indicator of behavioral depression postpartum （BDP） as it has been established as the core depressive-like behavior in primates. Monkeys were divided into two groups： A t3DP group （n=6）, which were found to spend more time huddling over the first two weeks postpartum than other individuals that formed a non-depression control group （n=4）. The two grou
Bibliography:53-1040/Q
Postpartum depression; Cynomolgus monkeys; Huddle behavior; Locomotion activity; Stressful events; Hair cortisol;Maternal relationship
Postpartum depression （PPD） is a modified form of major depressive disorders （MDD） that can exert profound negative effects on both mothers and infants than MDD. Within the postpartum period, both mothers and infants are susceptible; but because PPD typically occurs for short durations and has moderate symptoms, there exists challenges in exploring and addressing the underlying cause of the depression. This fact highlights the need for relevant animal models. In the present study, postpartum adult female cynomolgus monkeys （Macaca fascicularis） living in breeding groups were observed for typical depressive behavior. The huddle posture behavior was utilized as an indicator of behavioral depression postpartum （BDP） as it has been established as the core depressive-like behavior in primates. Monkeys were divided into two groups： A t3DP group （n=6）, which were found to spe
ISSN:0254-5853