Mechanism underlying the protective effect of Kaixin lieyu Fang on vascular depression following cerebral white matter damage

• Published in: 中国神经再生研究：英文版 Vol. 9; no. 1; pp. 61 - 68
• Main Author: Ying Zhang Shijing Huang Yanyun Wang Junhua Pan Jun Zheng Xianhui Zhang Yuxia Chen Duojiao Li
• Format: Journal Article
• Language: English
• Published: 2014
• Subjects: Bax蛋白; Bcl-2蛋白; mRNA表达; 保护作用; 抑郁症; 损伤机制; 脑白质; 血管
• ISSN: 1673-5374

The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression.