Mechanism underlying the protective effect of Kaixin lieyu Fang on vascular depression following cerebral white matter damage
The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily int...
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Published in | 中国神经再生研究:英文版 Vol. 9; no. 1; pp. 61 - 68 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
2014
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Subjects | |
Online Access | Get full text |
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Summary: | The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression. |
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Bibliography: | The Chinese compound Kaixin fieyu Fang can be used to treat vascular depression; however, the underlying mechanism remains unclear. This study established a rat model of chronic cerebral ischemia-caused white matter damage by ligation of the bilateral common carotid arteries. Rats received daily intragastric administration of a suspension of Kaixin ]ieyu Fang powder. After 3, 7 and 21 days of treatment, the degree of white matter damage in the cerebral ischemia rat model was alleviated, Bcl-2 protein and mRNA expression in brain tissue increased, and Bax protein and mRNA expression decreased. These results indicate that Kaixin Jieyu Fang can alleviate cere- bral white matter damage, and the underlying mechanism is associated with regulation of Bcl-2/ Bax protein and mRNA expression, which is one of possible mechanism behind the protective effect of Kaixin Jieyu Fang against vascular depression. nerve regeneration; vascular depression; ligation of the bilateral common carotid arteries;chronic cerebral ischemia; white matter damage; Kaixin ]ieyu Fang powder; Bcl-2; Bax; NSFC grant;neural regeneration Ying Zhang, Shijing Huang, Yanyun Wang, Junhua Pan, Jun Zheng, Xianhui Zhang, Yuxia Chen, Duojiao Li (Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China) 11-5422/R |
ISSN: | 1673-5374 |