Pretreatment with Jieduxiezhuo decoction impedes elevations in se- rum uric acid levels in mice

OBJECTIVE： To investigate whether Jieduxiezhuo decoction （JDXZD） can prevent serum uric acid ele- vations in mice. METHODS： Hyperuricemia in mice was induced by intraperitoneally administering uric acid （250 mg/ kg）. Concentrations of uric acid in serum were de- termined using the uric acid enzyme m...

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Published in中医杂志：英文版 no. 6; pp. 794 - 797
Main Author Yingyi Pan Zhifeng Chu Wenjuan Wang Baican Yang
Format Journal Article
LanguageEnglish
Published 2013
Subjects
小鼠
尿酸血症
朗姆酒
海拔
群体水平
腹腔注射
酸水
预处理
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Summary:OBJECTIVE： To investigate whether Jieduxiezhuo decoction （JDXZD） can prevent serum uric acid ele- vations in mice. METHODS： Hyperuricemia in mice was induced by intraperitoneally administering uric acid （250 mg/ kg）. Concentrations of uric acid in serum were de- termined using the uric acid enzyme method. Mice were treated with JDXZD for 4 days before uric acid was administered. RESULTS： After intraperitoneal injection of uric ac- id, serum uric acid concentrations in mice signifi- cantly increased. However, the levels of uric acid in groups pretreated with 16.25 or 4.06 g/kg of JDXZD were significantly lower than those in the model and normal groups. CONCLUSION： Pretreatment with JDXZD slowed in- creases in serum uric acid levels in mice intraperito-neally administered uric acid.
Bibliography:11-2167/R
OBJECTIVE： To investigate whether Jieduxiezhuo decoction （JDXZD） can prevent serum uric acid ele- vations in mice. METHODS： Hyperuricemia in mice was induced by intraperitoneally administering uric acid （250 mg/ kg）. Concentrations of uric acid in serum were de- termined using the uric acid enzyme method. Mice were treated with JDXZD for 4 days before uric acid was administered. RESULTS： After intraperitoneal injection of uric ac- id, serum uric acid concentrations in mice signifi- cantly increased. However, the levels of uric acid in groups pretreated with 16.25 or 4.06 g/kg of JDXZD were significantly lower than those in the model and normal groups. CONCLUSION： Pretreatment with JDXZD slowed in- creases in serum uric acid levels in mice intraperito-neally administered uric acid.
Uric acid; Hyperuricemia; Pretreatment;Jieduxiezhuo decoction
ISSN:0255-2922