局部麻醉药物治疗早泄的疗效和安全性：系统性回顾和荟萃分析

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Bibliographic Details
Published in亚洲男性学杂志：英文版 no. 4; pp. 497 - 502
Main Author Jia-Dong Xia You-Feng Hart Liu-Hua Zhou Yun Chen Yu-Tian Dai
Format Journal Article
LanguageEnglish
Published 2013
Subjects
局部麻醉药
早泄（PE）
系统性回顾
随机对照试验
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Bibliography:local anaesthetics; premature ejaculation （PE）; randomized controlled trial; systematic review
To assess the efficacy and safety of local anaesthetics for premature ejaculation （PE）, a systematic review of the literature was performed using the Cochrane Library, PUBMED and EMBASE. We screened and retrieved the randomized controlled trials on the treatment of PE with local anaesthetics. End points included intravaginal ejaculation latency time （IELT）, patient-reported outcome assessments and adverse events. Meta-analyses were conducted with Stata 11.0. In total, seven publications involving 566 patients with local anaesthetics and 388 with placebos strictly met our eligibility criteria. Meta-analyses showed that after the patients were treated with the local anaesthetics, the value of the standardized mean difference of the changes in IELT was 5.02 （95% Ch 3.03- 7.00）. A higher rate of adverse events occurred compared with placebos （odds ratio： 3.30, 95% Ch 1.71-6.36）, but these events were restricted to local side effects. In addition, significantly greater improvement was observed in patient-reported outcomes. In summary, local anaesthetics can prolong IELT and improve ejaculatory control and sexual satisfaction.
31-1795/R
ISSN:1008-682X
1745-7262