Retrospective study on Professor Zhongying Zhou＇s experience in Traditional Chinese Medicine treatment on diabetic nephropathy

• Published in: 中医杂志：英文版 no. 2; pp. 262 - 267
• Main Author: Kelei Su Fangshi Zhu Lizhong Guo Yao Zhu Wenlin Li Xingjiang Xiong
• Format: Journal Article
• Language: English
• Published: 2013
• Subjects: 中国传统医学; 发病机制; 挖掘技术; 标准化数据; 治疗; 活血化瘀; 病理因素; 糖尿病肾病
• ISSN: 0255-2922

OBJECTIVE： To study and analyze the etiology and pathogenesis, diagnosis and prescription for cases of diabetic nephropathy （DN） treated by Professor Zhongying Zhou （Prof. Zhou） with the help of dada mining technique, so as to inherit his clinical experi- ence and academic thoughts. METHODS; After pretreatment of the medical re- cord information, statistical software SPSS 13.0 was used to analyze and process the standardized data using the descriptive analysis, cluster analysis and association rules.RESULTS： Ninety-four entries derived from Tradi- tional Chinese Medicine （TCM） four-diagnostic in- formation were selected. Through data mining, the highest frequency was yellow-thin-greasy tongue coating, followed by dark tongue, and then by thready-slippery pulse. The main self-conscious symptoms were limb numbness, dry mouth, fre- quent micturition, etc. With respect to pathogene- sis, the etiology related to kidney reached 73.46%. The frequency of pathological factors for deficien- cy, blood stasis, heat, dampness, phlegm and dry- ness were 137.65%, 80.25%, 78.40%, 48.77%, 21.60%, and 14.20% respectively. A total of 236 kinds of herbs were used 2913 person times, aver- aging 17.98 herbs per prescription. CONCLUSION： The pathological location of DN is in the kidney. The pathogenesis of the disease is de- ficiency in origin and excess in superficiality, the for- mer of which include deficiency of the liver and kid- ney, and deficiency of both Qi and Yin. The main pathological factors are blood stasis, heat, damp- ness, phlegm, and dryness; and they act upon each other to form the complex pathogenesis in terms of blood stasis-heat, dampness-heat, phlegm-heat, and dryness-heat. All the above factors are always crucial in the aggravation of DN throughout the whole course of its pathological evolution.