Experimental Study on Topical Treatment of Diabetic Skin Ulcers with Yi Medicine ＂Yi Bu A Jie （以布阿节）＂ Extract

• Published in: 中国结合医学杂志：英文版 no. 6; pp. 464 - 467
• Main Author: 卢莉莉 万平 李利珍 赵梅君 胡佳耀 赵咏芳
• Format: Journal Article
• Language: English
• Published: 2013
• Subjects: 中性粒细胞; 外敷; 实验期; 提取物; 治疗; 皮肤溃疡; 糖尿病; 组织病理学
• ISSN: 1672-0415; 1993-0402

Objective： To study the role and mechanism of the Yi medicine, Yi Bu A Jie （以布阿节） extract, in topical treatment of diabetic skin ulcers, with a view to finding a breakthrough natural drug for the prevention and treatment of diabetic skin ulcers. Methods： A model of diabetic skin ulcers in Kunming mice was developed. Yi Bu A Jie was extracted in a Soxhlet extractor. Two different concentrations of the extract （0.005 mg/mL and 0.01 mg/mL） were applied to the wound of diabetic skin ulcers once every 3 days, and local skin appearance and histopathological changes were observed. Resalts： The shortest healing time was 25.25 ±2.06 day with a low concentration （P=0.0037 compared with the high concentration group, 33.14＋2.21 day; P=0.0082 compared with control group, 28.21 ± 2.14 days）. The longest healing time was in the high concentration group （P=0.0025 compared with the control group）. In both groups, a large number of inflammatory neutrophil cells were exuded dudng the experimental period. In the low concentration group, capillary-rich granulation tissue and actively growing fibroblasts appeared in the wound, while there was much necrotic tissue in the high concentration group. Conclusion： Yi Bu A Jie extract has an inhibitory effect on diabetic skin ulcers in mice, and the low concentration is more suitable.