肛门生殖器距离与雄激素受体基因CAG重复序列长度之间的关系

Saved in:
Bibliographic Details
Published in亚洲男性学杂志：英文版 no. 2; pp. 286 - 289
Main Author Michael L Eisenberg Tung-Chin Hsieh Alexander W Pastuszak Matthew G McIntyre Rustin C Waiters Dolores J Lamb Larry I Lipshultz
Format Journal Article
LanguageEnglish
Published 2013
Subjects
会阴
生殖器
肛门生殖器距离
阴茎长度
雄激素受体
Online AccessGet full text

Cover

More Information
Bibliography:Anogenital distance （AGD） is used to define degree of virilization of genital development, with shorter length being associated with feminization and male infertility. The first exon of the androgen receptor （AR） consists of a polymorphic sequence of cytosine-adenineguanine （CAG） repeats, with longer CAG repeat lengths being associated with decreased receptor function. We sought to determine if there is an association between AGD and AR CAG repeat length. A cross-sectional, prospective cohort of men evaluated at a urology clinic at a single institution was recruited. AGD （the distance from the posterior scrotum to the anal verge） and penile length （PL） were measured. Sanger DNA sequence analysis was used to define CAG repeat length. AGD and CAG repeat lengths in 195 men were determined. On unadjusted analysis, there was no linear relationship between CAG repeat length and PL （P=0.17） or AGD （P=-0.31）. However, on sub-population analyses, those men with longer CAG repeat lengths （〉26） had significantly shorter AGDs compared to men with shorter CAG repeat lengths. For example, the mean AGD was 41.9 vs. 32.4 mm with a CAG repeat length ≤26 vs. 〉26 （P=0.01）. In addition, when stratifying the cohort based on AGD, those with AGD less than the median （i.e. 40 mm） had a longer CAG repeat length compared to men with an AGD 〉40 mm （P=-0.02）. In summary, no linear relationship was found between AGD and AR CAG repeat length overall.
androgen receptor （AR）; anogenital distance （AGD）; genitalia; penile length （PL）; perineum
31-1795/R
ISSN:1008-682X
1745-7262