Synthesis and in vitro biological evaluation of famesylthiosalicylic acid derivatives as anti-tumor carcinoma agents

Novel farnesylthiosalicylic acid （PTA） derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5e, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lowe...

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Published in中国化学快报：英文版 Vol. 23; no. 10; pp. 1141 - 1144
Main Author Yong Ling You An Xiao Guang Tong Chen Dong Geng Wang Yu Qin Li Xin Yang Wang Heng Zheng
Format Journal Article
LanguageEnglish
Published 2012
Subjects
caspase
体外
合成
噻二唑衍生物
抗肿瘤活性
生物评价
癌细胞
肿瘤细胞凋亡
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Summary:Novel farnesylthiosalicylic acid （PTA） derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5e, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells.
Bibliography:11-2710/O6
Synthesis; Farnesylthiosalicylic acid; 1,3,4-Thiodiazole; Anti-tumor agents; Cytotoxic activities; Cell apoptosis
Novel farnesylthiosalicylic acid （PTA） derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5e, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells.
ISSN:1001-8417
1878-5964