A novel and efficient strategy for the synthesis of various carbamates using carbamoyl chlorides under solvent-free and grinding conditions usinz microwave irradiation

We present an efficient, fast and simple strategy of generating the intermediate carbamoyl chlorides from secondary amines using stoichiometric amounts of bis（trichloromethyl）carbonate （BTC） in solution and solvent-free conditions with excellent yields. The results obtained showed the yield increasi...

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Bibliographic Details
Published in中国化学快报：英文版 Vol. 23; no. 8; pp. 883 - 886
Main Author Hassan Zare Mohammad Mehdi Ghanbari Marzieh Jamali Abdollah Aboodi
Format Journal Article
LanguageEnglish
Published 2012
Subjects
双（三氯甲基）碳酸酯
反应时间
微波辐射
无溶剂条件
氨基甲酸酯
研磨条件
酯合成
酰氯
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Summary:We present an efficient, fast and simple strategy of generating the intermediate carbamoyl chlorides from secondary amines using stoichiometric amounts of bis（trichloromethyl）carbonate （BTC） in solution and solvent-free conditions with excellent yields. The results obtained showed the yield increasing on whether a base was used. Finally, an efficient and rapid synthesis of variety carbamate derivatives was developed by the reaction with a high variety of different alcohols, phenols, diols and this intermediate at room temperature with grinding and in solvent-free conditions under microwave irradiation. The presence of various safe bases is shown to be effective in reducing the reaction times, increasing the yields and easing purification. The present method does not involve any hazardous phosgene.
Bibliography:We present an efficient, fast and simple strategy of generating the intermediate carbamoyl chlorides from secondary amines using stoichiometric amounts of bis（trichloromethyl）carbonate （BTC） in solution and solvent-free conditions with excellent yields. The results obtained showed the yield increasing on whether a base was used. Finally, an efficient and rapid synthesis of variety carbamate derivatives was developed by the reaction with a high variety of different alcohols, phenols, diols and this intermediate at room temperature with grinding and in solvent-free conditions under microwave irradiation. The presence of various safe bases is shown to be effective in reducing the reaction times, increasing the yields and easing purification. The present method does not involve any hazardous phosgene.
11-2710/O6
Bis（trichloromethyl）carbonate; Carbamoyl chloride; Carbamate; Microwave irradiation; Solvent-free; Grinding
ISSN:1001-8417
1878-5964