Design,synthesis characterization and in vitro biological activity of a series of 3-aryl-6-（bromoarylmethyl）-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the novel acetylcholinesterase inhibitors

• Published in: 中国化学快报：英文版 Vol. 23; no. 7; pp. 765 - 768
• Main Author: He Nan Xu Zhe Jin Si Jie Liu Hong Min Liu Shuo Li Huang Quan Lin David Chicheong Wan Chun Hu
• Format: Journal Article
• Language: English
• Published: 2012
• Subjects: 三嗪; 乙酰胆碱酯酶抑制剂; 合成表征; 噻唑; 对接设计; 生物活性; 芳基; 酮衍生物
• ISSN: 1001-8417; 1878-5964

Bromination is used as a strategy to improve biological activity in medicinal chemistry.In order to study on the structure-activity relationships of the novel acetylcholinesterase inhibitors with 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one scaffold,based on our previous work and molecular modeling,a series of novel 3-aryl-6-（bromoarylrnethyl）-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were designed by molecular docking,synthesized and characterized by mass spectra,infrared spectra,proton NMR and elemental analyses.The study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as the positive control.Most of all target compounds exhibited more than 45%inhibition at 10μmol/L.The preliminary structureactivity relationship was the bromine atoms and the hydroxyl group at the phenyl ring at the C6 position of the parent nucleus played significant roles in the AChE inhibitory activity of the target compounds.