mpulse magnetic stimulation facilitates synaptic regeneration in rats following sciatic nerve injury

• Published in: 中国神经再生研究：英文版 Vol. 7; no. 17; pp. 1299 - 1303
• Main Author: Sergey A. Zhivolupov Miroslav M. Odinak Nariman A. Rashidov Ludmila S. Onischenko Igor N. Samartsev Anton A. Jurin
• Format: Journal Article
• Language: English
• Published: 2012
• Subjects: 再生; 周围神经损伤; 大鼠; 电子显微镜; 神经可塑性; 神经系统疾病; 突触; 经颅磁刺激
• ISSN: 1673-5374

The current studies describing magnetic stimulation for treatment of nervous system diseases mainly focus on transcranial magnetic stimulation and rarely focus on spinal cord magnetic stimulation. Spinal cord magnetic stimulation has been confirmed to promote neural plasticity after injuries of spinal cord, brain and peripheral nerve. To evaluate the effects of impulse magnetic stimulation of the spinal cord on peripheral nerve regneration, we compressed a 3 mm segment located in the middle third of the hip using a sterilized artery forceps to induce ischemia. Then, all animals underwent impulse magnetic stimulation of the lumbar portion of spinal crod and spinal nerve roots daily for 1 month. Electron microscopy results showed that in and below the injuryed segment, the inflammation and demyelination of neural tissue were alleviated, apoptotic cells were reduced, and injured Schwann cells and myelin fibers were repaired. These findings suggest that high-frequency impulse magnetic stimulation of spinal cord and corresponding spinal nerve roots promotes synaptic regeneration following sciatic nerve injury.