Synthesis and in vivo distribution of 2-deoxy-2-aminodiglucose-prednisolone conjugate（DPC）

In order to develop a novel kidney-targeted drug delivery system,a small molecular carrier（2-deoxy-2-aminodiglucose） was synthesized,and then the 2-deoxy-2-aminodiglucose-prednisolone conjugate（DPC） was synthesized to verify the kidney targeting capability of the carrier.Both 2-deoxy-2-aminodiglucos...

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Published in中国化学快报：英文版 Vol. 23; no. 5; pp. 557 - 560
Main Author Yan Lin Xun Sun Tao Gong Zhi Rong Zhang
Format Journal Article
LanguageEnglish
Published 2012
Subjects
DPC
体内
共轭
合成
强的松
脱氧
靶向给药系统
靶向载体
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Summary:In order to develop a novel kidney-targeted drug delivery system,a small molecular carrier（2-deoxy-2-aminodiglucose） was synthesized,and then the 2-deoxy-2-aminodiglucose-prednisolone conjugate（DPC） was synthesized to verify the kidney targeting capability of the carrier.Both 2-deoxy-2-aminodiglucose and DPC were confirmed by NMR and MS spectrum.The tissue distribution studies showed that DPC presented an excellent kidney targeting property in vivo,compared with prednisolone group, 4.9-fold of drug concentration in kidney was observed in the DPC group.Thus,it indicated that 2-deoxy-2-aminodiglucose could be a potential carrier for kidney-targeted drug delivery.
Bibliography:11-2710/O6
Yan Lin,Xun Sun,Tao Gong,Zhi Rong Zhang Key Laboratory of Drug Targeting of Ministry of Education,West China School of Pharmacy,Sichuan University,Chengdu 610041,China
In order to develop a novel kidney-targeted drug delivery system,a small molecular carrier（2-deoxy-2-aminodiglucose） was synthesized,and then the 2-deoxy-2-aminodiglucose-prednisolone conjugate（DPC） was synthesized to verify the kidney targeting capability of the carrier.Both 2-deoxy-2-aminodiglucose and DPC were confirmed by NMR and MS spectrum.The tissue distribution studies showed that DPC presented an excellent kidney targeting property in vivo,compared with prednisolone group, 4.9-fold of drug concentration in kidney was observed in the DPC group.Thus,it indicated that 2-deoxy-2-aminodiglucose could be a potential carrier for kidney-targeted drug delivery.
Synthesis; 2-Deoxy-2-aminodiglucose; Prednisolone; Tissue distribution
ISSN:1001-8417
1878-5964