Association between TaqlB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population

• Published in: 浙江大学学报：B卷英文版 Vol. 13; no. 5; pp. 342 - 347
• Main Author: Qi YU En-qi LIU Si-hai ZHAO Ya-feng LI Yan-li WANG Yu-long CHEN Ke-na WEI Bing-qiao HUANG Jian-lin FAN Peng-hui YANG
• Format: Journal Article
• Language: English
• Published: 2012
• ISSN: 1673-1581; 1862-1783

Objective： To assess whether the TaqlB polymorphism of cholesteryl ester transfer protein （CETP） is associated with coronary artery disease （CAD） in Chinese population, we performed a meta-analysis in this paper. Methods： We searched PubMed, Embase, the Science Citation Index （SCI）, the China Biological Medicine database （CBM）, the China National Knowledge Infrastructure （CNKI）, and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios （ORs） and 95% confidence intervals （CIs） were calculated. Results： The lit- erature search yielded 448 studies, in which 10 case-control studies including 1 694 cases and 1 456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 （95% （31, 0.89-1.34） for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 （95% CI, 1.09-1.49） in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions： In the present study, the TaqlB polymorphism of CETP was found to be associated with CAD in the Chinese population.