累及野调强放疗联合同步化疗治疗局部晚期非小细胞肺癌的疗效观察

目的比较累及野照射（IFI）和选择性淋巴结照射（ENI）调强放射治疗联合同步化疗治疗局部晚期非小细胞肺癌（LA-NSCLC）的不良反应和疗效。方法 49例LA-NSCLC患者前瞻性随机分为IFI组和ENI组,同步化疗两周期,行根治性调强放射治疗。结果 IFI组和ENI组≥2级放射性肺炎发生率分别为8.0%和37.5%（P=0.01）;GTV平均剂量分别是（66.2±6.5）Gy和（61.3±6.3）Gy,（P=0.01）;总有效率为92.0%和66.7%（P=0.03）;预防照射区内淋巴结复发率为4.2%和4.0%,（P=0.49）;1年局部失败率分别为8.0%和16.7%（P=0.62）;1...

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Published in肿瘤防治研究 Vol. 39; no. 3; pp. 321 - 323
Main Author 姚元虎 章龙珍 吴阳 辛勇 唐天友 王建设 张鑫君 覃朝晖
Format Journal Article
LanguageChinese
Published 2012
Subjects
照射野
调强放射治疗
非小细胞肺癌
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ISSN1000-8578

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Summary:目的比较累及野照射（IFI）和选择性淋巴结照射（ENI）调强放射治疗联合同步化疗治疗局部晚期非小细胞肺癌（LA-NSCLC）的不良反应和疗效。方法 49例LA-NSCLC患者前瞻性随机分为IFI组和ENI组,同步化疗两周期,行根治性调强放射治疗。结果 IFI组和ENI组≥2级放射性肺炎发生率分别为8.0%和37.5%（P=0.01）;GTV平均剂量分别是（66.2±6.5）Gy和（61.3±6.3）Gy,（P=0.01）;总有效率为92.0%和66.7%（P=0.03）;预防照射区内淋巴结复发率为4.2%和4.0%,（P=0.49）;1年局部失败率分别为8.0%和16.7%（P=0.62）;1年生存率为72.0%和62.5%（P=0.48）。结论 IFI同步放化疗治疗LA-NSCLC可降低正常组织并发症的概率,提高靶区照射剂量和肿瘤控制率,预防照射区内淋巴结复发率无增加,有望延长患者生存期。
Bibliography:42-1241/R
Yao Yuanhu,Zhang Longzhen,Wu Yang,Xin Yong,Tang Tianyou,Wang Jianshe,Zhang Xinjun,Qin Zhaohui Department of Radiation Oncology,Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China
Non-small cell lung cancer; Intensity modulated radiation therapy; Irradiation field size
Objective To compare toxicities and clinical outcomes of involved field irradiation（IFI）and with elective nodal irradiation（ENI）intensity modulated radiation therapy（IMRT）with concurrent chemotherapy for locally advanced non-small cell lung cancer（LA-NSCLC）.Methods 49 patients with of LA-NSCLC were prospectively randomized into IFI group and ENI group,receiving 2 cycles of concurrent chemotherapy and radical IMRT.Results ≥grade 2 radiation pneumonitis developed in 8.0% of the patients in IFI group and 37.5% in ENI group（P=0.01）.The mean prescription doses to grass tumor volumes with IFI and ENI were（66.2±6.5）Gy and（61.3±6.3）Gy（P=0.01）.The responsive rates were 92.0% and 66.7%（P=0.03）,and the elective nodal failure（ENF）rates
ISSN:1000-8578