A Facile One-Pot Three-Component Synthesis of 5-（Trifl uoromethyl）-4,7-dihyd ro-[1,2,4]-triazolo[1,5-a] pyrimidine Derivatives in Ionic Liquid

• Published in: 中国化学：英文版 Vol. 29; no. 11; pp. 2427 - 2432
• Main Author: 李团结 姚昌盛 雷松 于晨侠 屠树江
• Format: Journal Article
• Language: English
• Published: 2011
• Subjects: 一锅合成; 三唑并; 三氟甲基; 三组分; 乙酸乙酯; 反应条件; 嘧啶衍生物; 离子液体

An efficient one-pot synthesis of 5-（trifluoromethyl）-4,7-dihydro-7-aryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3-amino-l,2,4-triazole and ethyl 4,4,4-trifluoro-3- oxobutanoate or 4,4,4-trifluoro-l-phenylbutane-1,3-dione in ionic liquid. This me...