A Facile One-Pot Three-Component Synthesis of 5-（Trifl uoromethyl）-4,7-dihyd ro-[1,2,4]-triazolo[1,5-a] pyrimidine Derivatives in Ionic Liquid

An efficient one-pot synthesis of 5-（trifluoromethyl）-4,7-dihydro-7-aryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3-amino-l,2,4-triazole and ethyl 4,4,4-trifluoro-3- oxobutanoate or 4,4,4-trifluoro-l-phenylbutane-1,3-dione in ionic liquid. This me...

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Published in中国化学：英文版 Vol. 29; no. 11; pp. 2427 - 2432
Main Author 李团结 姚昌盛 雷松 于晨侠 屠树江
Format Journal Article
LanguageEnglish
Published 2011
Subjects
一锅合成
三唑并
三氟甲基
三组分
乙酸乙酯
反应条件
嘧啶衍生物
离子液体
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Summary:An efficient one-pot synthesis of 5-（trifluoromethyl）-4,7-dihydro-7-aryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3-amino-l,2,4-triazole and ethyl 4,4,4-trifluoro-3- oxobutanoate or 4,4,4-trifluoro-l-phenylbutane-1,3-dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, mild reaction conditions, high yields and eco-friendliness.
Bibliography:multicomponent reaction, trifluoromethyl, triazolo[1,5-a]pyrimidine, ionic liquid
An efficient one-pot synthesis of 5-（trifluoromethyl）-4,7-dihydro-7-aryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives was performed via the reaction of aryl aldehyde, 3-amino-l,2,4-triazole and ethyl 4,4,4-trifluoro-3- oxobutanoate or 4,4,4-trifluoro-l-phenylbutane-1,3-dione in ionic liquid. This method has the advantages of short synthetic route, operational simplicities, mild reaction conditions, high yields and eco-friendliness.
31-1547/O6
Li, Tuanjie Yao, Changsheng Lei, Song Yu, Chenxia Tu, Shujianga a School of Chemistry and Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China b School of Chemistry and Engineering, Key Laboratory ofBiotechnologyfor Medicial Plant, Xuzhou Normal University, Xuzhou, Jiangsu 221116, China
ISSN:1001-604X
1614-7065