瞬时弹性成像诊断肝脏纤维化的准确性研究

目的评估瞬时弹性成像（FibroScan）诊断肝纤维化的准确性。方法选取解放军302医院2009年4-12月经病理检查诊断为肝纤维化的患者323例,其中141例患者行肝活检病理检查。全部患者临床检测肝功能、凝血指标、B超、血细胞计数,部分患者检测肝纤维化4项,患者均同时应用FibroScan进行肝脏硬度检测（LSM）值测量。分析肝脏硬度与血清学指标及肝纤维化程度的相关性,采用受试者工作特征（ROC）曲线分析FibroScan诊断肝纤维化的准确性。结果 323例患者各项血清学指标与肝脏硬度值均显著相关（P〈0.001）,肝脏硬度与肝纤维化程度显著相关（r=0.74,P〈0.001）。其中141例...

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Published in解放军医学杂志 Vol. 36; no. 11; pp. 1134 - 1135
Main Author 张健 韩萍 邵清 纪冬 陈松海 王春艳 陈国凤
Format Journal Article
LanguageChinese
Published 2011
Subjects
瞬时弹性成像
肝硬化
诊断
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Summary:目的评估瞬时弹性成像（FibroScan）诊断肝纤维化的准确性。方法选取解放军302医院2009年4-12月经病理检查诊断为肝纤维化的患者323例,其中141例患者行肝活检病理检查。全部患者临床检测肝功能、凝血指标、B超、血细胞计数,部分患者检测肝纤维化4项,患者均同时应用FibroScan进行肝脏硬度检测（LSM）值测量。分析肝脏硬度与血清学指标及肝纤维化程度的相关性,采用受试者工作特征（ROC）曲线分析FibroScan诊断肝纤维化的准确性。结果 323例患者各项血清学指标与肝脏硬度值均显著相关（P〈0.001）,肝脏硬度与肝纤维化程度显著相关（r=0.74,P〈0.001）。其中141例行病理检查的患者统计结果显示,F1、F2、F3、F4期肝纤维化的ROC曲线下面积（AUROC）分别为0.97（0.94,1.00）、0.96（0.93,0.99）、0.99（0.98,1.00）、0.97（0.94,0.99）,诊断界值分别为4.4、6.8、9.7、10.0kPa。结论 FibroScan对肝纤维化的诊断价值较高,可作为慢性肝病患者跟踪随访和管理的依据。
Bibliography:Objective To evaluate the accuracy of transient elastometry（FibroScan） for the detection of liver fibrosis.Methods A total of 323 patients diagnosed with chronic liver disease based on pathological examination in the 302 Hospital of the People’s Liberation Army from April to December of 2009 were involved in the current study.Among them,141 patients were subjected to liver biopsy.Their liver function,coagulant index,B-ultrasound and blood cell count were examined clinically.Four examinations related to liver fibrosis were done on some of the patients.Meanwhile,FibroScan was used for liver stiffness measurement（LSM） of every patient.The correlation between liver stiffness and the serologic index and liver fibrosis degree was analyzed.The Receive Operating Characteristic（ROC） curve was adopted to analyze the accuracy of FibroScan for diagnosing liver fibrosis.Results Each serologic index was significantly correlated with liver stiffness（P〈0.001）,and liver stiffness was closely related to the stage of liver fibr
ISSN:0577-7402