Effects of Liandou Qingmai Recipe（连豆清脉方） on Endothelin-1,Nitric Oxide,Interleukin-6 and Interleukin-10 Levels in Patients with Coronary Heart Disease

• Published in: 中医杂志：英文版 Vol. 31; no. 3; pp. 173 - 177
• Main Author: 朱红俊 陆曙 苏伟 龚少愚 张志斌 李萍 魏慧渊 杨庆有 唐虹 夏成霞 朱明
• Format: Journal Article
• Language: English
• Published: 2011
• Subjects: 一氧化氮; 内皮素-1; 冠心病; 患者; 水; 白细胞介素-6; 血管内皮功能; 配方
• ISSN: 0255-2922

Objective：To observe effects of Liandou Qingmai Recipe（连豆清脉方） on endothelin-1（ET-1）,nitric oxide（NO）,interleukin-6（IL-6） and IL-10 levels in patients with coronary heart disease.Methods：Total 101 cases with coronary heart disease were randomly divided into a treatment group（n=45） treated by Liandou Qingmai Recipe and a standard treatment group（control group,n=56）,with a normal group of 16 health persons set up.Changes of ET-1,NO,IL-6 and IL-10 levels were measured before treatment and after treatment for two weeks.And the data were analyzed by SPSS 16.0 statistic software.Results：Before treatment,the levels of ET-1,IL-6 and IL-10 levels were significantly higher and NO was significantly lower in the patients with coronary heart disease than those in the normal group（90.7±12.7 ng/L vs 41.8±13.5 ng/L,9.17±0.18 ng/L vs 1.10±0.08 ng/L,1.94±0.26 ng/L vs 1.09±0.06 ng/L,and 92.2±17.7 μmol/L vs 124.5±27.2 μmol/L;all P0.05）,with no significant differences in the levels of ET-1,NO,IL-6 and IL-10 between the treatment group and the control group（P0.05）;After treatment,ET-1 and IL-6 significantly decreased in the treatment group and the control group,and NO increased in the treatment group;And IL-6 level was significantly lower and NO level was higher in the treatment group than those in the control group（4.48±1.22 ng/L vs 5.13±1.85 ng/L,117.4±22.3 μmol/L vs 92.4±17.1 μmol/L;both P0.05）;There was a positive correlation between IL-6 and IL-10,and a negative correlation between NO and IL-10（r=0.142,r=-0.152;both P0.05）.Conclusion：Liandou Qingmai Recipe can decline IL-6,IL-10 and ET-1 levels,and raise NO level in patients with coronary heart disease on the basis of standard treatment,so as to inhibit endothelial inflammatory response,improve vascular endothelial function,with stronger anti-AS action;And vascular endothelial lesion is related with inflammatory response.