Crystal structure and DNA binding studies of a cobalt（Ⅱ） complex containing mixed-ligands of 1,10-phenathroline and glycollic acid
A cobalt（11） complex containing mixed-ligands of 1,10-phenathroline（phen） and glycollic acid（GA）.｜Co（GA）_2（phen）｜ was synthesized and its structure was characterized by X-ray diffraction.The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical met...
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| Published in | 中国化学快报：英文版 Vol. 22; no. 8; pp. 969 - 972 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
2011
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| Subjects | |
| Online Access | Get full text |
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| Summary: | A cobalt（11） complex containing mixed-ligands of 1,10-phenathroline（phen） and glycollic acid（GA）.｜Co（GA）_2（phen）｜ was synthesized and its structure was characterized by X-ray diffraction.The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods.Electronic absorption spectrum experiments showed that after interaction with DNA.the characteristic absorption peaks of ｜Co（GA）_2（phen）｜ underwent hypochromic effect as well as redshift. Also,the binding strength of 3.8×10~4L/mol was estimated by titration method.Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA.All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode. |
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| Bibliography: | 11-2710/O6 Cobalt complex; DNA binding; Electronic absorption spectra; Electrochemistry A cobalt（11） complex containing mixed-ligands of 1,10-phenathroline（phen） and glycollic acid（GA）.｜Co（GA）_2（phen）｜ was synthesized and its structure was characterized by X-ray diffraction.The interaction of the complex with DNA was investigated by electronic absorption spectra and electrochemical methods.Electronic absorption spectrum experiments showed that after interaction with DNA.the characteristic absorption peaks of ｜Co（GA）_2（phen）｜ underwent hypochromic effect as well as redshift. Also,the binding strength of 3.8×10~4L/mol was estimated by titration method.Electrochemical assays revealed that the redox peak currents of the complex decreased obviously accompanied by a positive shift of the formal potential after association with DNA.All these results revealed that the synthesized cobalt complex bound with DNA via an intercalation mode. Hai Bin Lin,Qing Xiang Wang,Cong Min Zhang,Wen Qi Li a Department of Chemistry and Environmental Science,Zhangzhou Normal University,Zhangzhou 363000,China b Department of Bioscience with Technique,Zhangzhou Normal University,Zhangzhou 363000,China |
| ISSN: | 1001-8417 1878-5964 |