gem-Dimethyl-bearing C-Glucosides as Sodium-glucose Co-transporter 2 (SGLT2) Inhibitors
Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 (SGLT2) inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a facile 8-step protocol, with the key step being anhydrous aluminum chloride-catalyzed...
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Published in | 中国化学:英文版 Vol. 29; no. 6; pp. 1192 - 1198 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
2011
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Subjects | |
Online Access | Get full text |
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Summary: | Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 (SGLT2) inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a facile 8-step protocol, with the key step being anhydrous aluminum chloride-catalyzed Friedel-Crafts alkylation of tertiary alcohols and phenetol. These three SGLT2 inhibitors were evaluated in vivo with a mice oral glucose tolerance test (OGTT), and the anti-hyperglycemic activities of all these three compounds were comparable with that of the positive control Dapagliflozin. |
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Bibliography: | sodium-glucose co-transporter 2 (SGLT2), gem-dimethyl, synthesis, Friedel-Crafts alkylation, oral glucose tolerance test (OGTT) 31-1547/O6 Three novel gem-dimethyl C-glucosides were designed as sodium-glucose co-transporter 2 (SGLT2) inhibitors, and their syntheses started from D-glucose and three 2-substituted-5-bromobenzoic acids were achieved via a facile 8-step protocol, with the key step being anhydrous aluminum chloride-catalyzed Friedel-Crafts alkylation of tertiary alcohols and phenetol. These three SGLT2 inhibitors were evaluated in vivo with a mice oral glucose tolerance test (OGTT), and the anti-hyperglycemic activities of all these three compounds were comparable with that of the positive control Dapagliflozin. |
ISSN: | 1001-604X 1614-7065 |