不同放疗技术在胃癌术后放疗中的剂量学研究

目的比较胃癌三维适形放疗（3DCRT）、7野分野放疗（7FRT）与调强放射治疗（IMRT）三种技术的剂量学差异,为临床应用提供参考。方法选取5名在本院行胃癌根治术后的胃癌患者。每名患者制定上述三种放疗计划,给予95%PTV45Gy的处方剂量,用等剂量曲线和剂量体积直方图（DVH）评价治疗计划,评价参数包括V95%、V110%、适形指数（CI）、不均匀性指数（HI）、外部体积指数（EI）及正常组织受照剂量。结果靶区适形性IMRT优于3DCRT及7FRT（P〈0.05）,3DCRT与7FRT差异无统计学意义（P〉0.05）;靶区剂量分布均匀性,IMRT优于3DCRT及7FRT（P〈0.05）,3D...

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Bibliographic Details
Published in肿瘤防治研究 Vol. 38; no. 5; pp. 571 - 574
Main Author 罗居东 李兆斌 章青 傅深 王建华 卢绪菁 汤华 孔颖泽
Format Journal Article
LanguageChinese
Published 2011
Subjects
剂量学
放射疗法
放疗技术
胃癌
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Summary:目的比较胃癌三维适形放疗（3DCRT）、7野分野放疗（7FRT）与调强放射治疗（IMRT）三种技术的剂量学差异,为临床应用提供参考。方法选取5名在本院行胃癌根治术后的胃癌患者。每名患者制定上述三种放疗计划,给予95%PTV45Gy的处方剂量,用等剂量曲线和剂量体积直方图（DVH）评价治疗计划,评价参数包括V95%、V110%、适形指数（CI）、不均匀性指数（HI）、外部体积指数（EI）及正常组织受照剂量。结果靶区适形性IMRT优于3DCRT及7FRT（P〈0.05）,3DCRT与7FRT差异无统计学意义（P〉0.05）;靶区剂量分布均匀性,IMRT优于3DCRT及7FRT（P〈0.05）,3DCRT优于7FRT（P〈0.05）;外部体积指数IMRT优于3DCRT及7FRT（P〈0.05）,3DCRT与7FRT无明显统计学差异（P〉0.05）;IMRT对肝脏的保护优于优于3DCRT及7FRT（P〈0.05）,7FRT的肝脏D1/3优于3DCRT（P〈0.05）,3DCRT与7FRT在肝脏受到的平均剂量（Dmean）上差异无统计学意义（P〉0.05）;脊髓的最高受量（Dmax）：3DCRT优于7FRT及IMRT（P〈0.05）,7FRT优于IMRT（P〈0.05）;3DCRT、7FRT及IMRT在肾脏的受量上差异无统计学意义。结论 IMRT优于3DCRT及7FRT;3DCRT的HI、脊髓Dmax优于7FRT。7FRT的肝脏D1/3优于3 DCRT。IMRT对于胃癌放疗具有放射物理的优势。
Bibliography:Gastric cancer; Radiotherapy; Radiotherapy technology; Dosimetry
42-1241/R
Objective To compare the dose distributions and dose-volume histograms（DVHs） in critical organs of three-dimensional conformal radiotherapy（3DCRT）,7 fields radiotherapy（7FRT） and intensity modulated radiation therapy（IMRT） through the analysis of planning target volume（PTV） in gastric cancer treatment.Methods Five patients with pathologically confirmed stage T3,T4 N0M0 gastric carcinoma who underwent radical gastrectomy were enrolled in our study.Dosimetry studies were carried out by three different treatment planning,such as 3DCRT,7FRT or IMRT,in which each patient was prescribed a dose of 45Gy to 95% of PTV.The parameters of isodose distributions line,dose-volume histogram（DVH）,V95%,V110%,CI,HI,EI of target volume and the dose of related critical organs were investigated.Results IMRT showed best dose uniformity and conformity,EI than 3DCRT and 7FRT（P0.05）,and there was no statistical difference between 3DCRT and 7FRT in CI and EI（P0.05
ISSN:1000-8578