Radiotherapy of unicentric mediastinal Castleman＇s disease

Castleman＇s disease is a slowly progressive and rare lymphoproliferative disorder. Here, we report a 55-year-old woman with superior mediastinal Castleman＇s disease being misdiagnosed for a long term. We found a 4.3 cm mass localized in the superior mediastinum accompanied with severe clinical sympt...

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Bibliographic Details
Published in癌症 Vol. 30; no. 5; pp. 351 - 356
Main Author Yue-Min Li Peng-Hui Liu Yu-Hai Zhang Huo-Sheng Xia Liang-Liang Li Yi-Mei Qu Yong wu Shou-Yun Han Guo-Qing Liao Yong-Dong Pu
Format Journal Article
LanguageChinese
Published 2011
Subjects
临床症状
剖腹
增生性
放射治疗
放疗
本地化
淋巴组织
病理检查
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Summary:Castleman＇s disease is a slowly progressive and rare lymphoproliferative disorder. Here, we report a 55-year-old woman with superior mediastinal Castleman＇s disease being misdiagnosed for a long term. We found a 4.3 cm mass localized in the superior mediastinum accompanied with severe clinical symptoms. The patient underwent an exploratory laparotomy, but the mass failed to be totally excised. Pathologic examination revealed a mediastinal mass of Castleman＇s disease. After radiotherapy of 30 Gy by 15 fractions, the patient no longer presented previous symptoms. At 3 months after radiotherapy of 60 Gy by 30 fractions, Computed tomography of the chest showed significantly smaller mass, indicating partial remission. Upon a 10-month follow-up, the patient was alive and free of symptoms.
Bibliography:Castleman＇s disease is a slowly progressive and rare lymphoproliferative disorder. Here, we report a 55-year-old woman with superior mediastinal Castleman＇s disease being misdiagnosed for a long term. We found a 4.3 cm mass localized in the superior mediastinum accompanied with severe clinical symptoms. The patient underwent an exploratory laparotomy, but the mass failed to be totally excised. Pathologic examination revealed a mediastinal mass of Castleman＇s disease. After radiotherapy of 30 Gy by 15 fractions, the patient no longer presented previous symptoms. At 3 months after radiotherapy of 60 Gy by 30 fractions, Computed tomography of the chest showed significantly smaller mass, indicating partial remission. Upon a 10-month follow-up, the patient was alive and free of symptoms.
Castleman＇s disease; radiotherapy; case report
Yue-Min Li, Peng-Hui Liu, Yu-Hai Zhang, Huo-Sheng Xia, Liang-Liang Li, Yi-Mei Qu, Yong Wu, Shou-Yun Han, Guo-Qing Liao, Yong-Dong Pu（ 1.Cancer Center, PLA 309 Hospital, Beijing 100091,
ISSN:1000-467X
1944-446X