Solid state reactions of nitrogenous heterocyclic compounds (Ⅱ)——Solid state reactions of indole with carbonyl compounds

Solid state Michael addition reaction of indole with α,β-unsaturaled carbonyl compounds was carried out,by which a series of compounds containing three different heterocyclic groups binding to one carbon atom were obtained.In the presence of Lewis acid,indole could undergo the solid state condensati...

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Published in中国科学：化学英文版 no. 3; pp. 270 - 277
Main Author 李晓陆 王永梅 杜大明 文忠 熊国祥 孟继本
Format Journal Article
LanguageEnglish
Published 1997
Subjects
addition
compound
indole
Michael
nitrogenous
reaction
solid
state
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Summary:Solid state Michael addition reaction of indole with α,β-unsaturaled carbonyl compounds was carried out,by which a series of compounds containing three different heterocyclic groups binding to one carbon atom were obtained.In the presence of Lewis acid,indole could undergo the solid state condensation reaction with aromatic ketones and aldehydes or quinones.The solid state reaction showed higher selectivity and yield than solution reaction The structures of products were identified by IR,1H NMR,MS,elemental analysis and X-ray crystal analysis.The reaction mechanism was also proposed.
Bibliography:LI Xiaoliu WANG Yongmei DU DamingWEN Zhong,XIONG Guoxiang and MENG Jiben(Department of Chemistry,Nankai University,Tianjin 300071,China)
11-5839/O6
ISSN:1674-7291
1869-1870