Electron microscopic investigation of anterior lens capsule in an individual with true exfoliation

·AIM: To determine the changes which occur in the anterior capsule in true exfoliation which is a very rare condition. ·METHODS: The anterior capsule from a 93 year-old patient and 6 other patients with age -related cataract during capsulorhexis was examined transmission electron microscopy (TEM). ·...

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Published in国际眼科杂志：英文版 no. 4; pp. 553 - 556
Main Author Xing-Chao Shentu Ya-Nan Zhu Ying-Hui Gao Su-Juan Zhao Ye-Lei Tang
Format Journal Article
LanguageEnglish
Published 2013
Subjects
age-related
apoptosis
cataract
electron
exfoliation
microscopy
transmission
true
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Summary:·AIM: To determine the changes which occur in the anterior capsule in true exfoliation which is a very rare condition. ·METHODS: The anterior capsule from a 93 year-old patient and 6 other patients with age -related cataract during capsulorhexis was examined transmission electron microscopy (TEM). ·RESULTS: TEM revealed apoptosis of lens epithelial cells in both two groups. Moreover, we observed lamellar delamination, granular belts in the anterior capsular zone and loss of the subcapsular epithelium cells in the posterior capsular zone, as well as abnormal fibrils located in the central capsular layer only in the sample from the patient with true exfoliation. ·CONCLUSION: We suggest that loss of lens epithelial cells and appearance of abnormal fibrils is important in disease developing, and our study supported age-related degeneration is one of causative factors in true exfoliation.
Bibliography:Xing-Chao Shentu1,Ya-Nan Zhu1,Ying-Hui Gao1,Su-Juan Zhao1,Ye-Lei Tang2 1 Eye Center, the 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, Zhejiang Province, China 2 Department of Neurology, the 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
ISSN:2222-3959
2227-4898