Influence of a-tocopherol on nickel induced alteration of serum lipid profile in male albino rats

<正>We studied the effect of the simultaneous treatment withα-tocopherol(100 mg / kg;im) and nickel sulfate (20 mg/kg,ip) on nickel-induced changes in serum lipid profiles.Nickel-treated rats showed a significant increase in serum LDL cholesterol,total cholesterol,triglycerides,and a si...

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Published in亚太热带医药杂志：英文版 no. 1; pp. 14 - 18
Main Author Gupta AD Dhundasi SA Dhara PC Das KK
Format Journal Article
LanguageEnglish
Published 2008
Subjects
lipid
nickel
profile
serum
sulfate
α-tocopherol
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Summary:<正>We studied the effect of the simultaneous treatment withα-tocopherol(100 mg / kg;im) and nickel sulfate (20 mg/kg,ip) on nickel-induced changes in serum lipid profiles.Nickel-treated rats showed a significant increase in serum LDL cholesterol,total cholesterol,triglycerides,and a significant decrease in serum HDL cholesterol. Simultaneous administration ofα-tocopherol with nickel sulfate improved LDL-cholesterol and HDLcholesterol level when compared with rats receiving nickel sulfate alone.The results indicate thatα-tocopherol is beneficial in preventing nickel-induced lipid profile alterations.
Bibliography:Gupta AD1,Dhundasi SA1,Dhara PC2,Das KK1 1 Department of Physiology,Al-Ameen Medical College,Bijapur 586108 Karnataka,India 2 Department of Human Physiology & Community Health,Vidyasagar University,Midnapur(West) 721102,West Bengal,India
ISSN:1995-7645
2352-4146