Effect of HbA1c combined FPG on screening diabetes in health checkup

• Published in: 亚太热带医药杂志：英文版 no. 6; pp. 472 - 475
• Main Author: Li-Juan Li Jing-Xia Zhou Guang-Tao Chen Yan-Ling Song Yao-Ming Xue
• Format: Journal Article
• Language: English
• Published: 2012
• Subjects: checkup; Diabetes; HbA1c; Health; Screening
• ISSN: 1995-7645; 2352-4146

<正>Objective:To appraise the effectiveness of HbA1c and fasting plasma glucose（FPG） on screening diabetes in health check-up.Methods:A total of 1 337 individuals（male 850,female 487）,aged 27 to 91 years with HbA1c test were included.Participates with HbA1c≥6.0%or FPG≥6.1 mmol/ L underwent oral glucose tolerance test（OGTT）.Diabetes mellitus was diagnosed according to the criteria of WHO in 1999,FPG≥7.0 mmol/L and/or OGTT 2 h-postload plasm glucose（2 h-PG）≥11.1 mmol/L.The sensitivity and specificity of HbA1c thresholds and FPG or combination test on screening of diabetes were analyzed.Results:A total of 842 subjects had HbA1c<6.0%,in which 32 had isolated FPG≥6.1 mmol/L,of 495 had HbA1c≥6.0%.Subjects with HbA1c≥6.0% had significant increased disorder indexes than those with HbA1c<6.0%.527 subjects who had HbA1c≥6.0%or FPG≥6.1 mmol/L underwent OGTT.A total of 234 subjects were newly diagnosed diabetes,including 123（123/234,52.56%） with FPG≥7.0 mmol/L,and 111 subjects（111/234, 47.43%） with isolated 2 h-PG≥11.1 mmol/L.Among 234 new diabetes,91.88%（215 subjects） had HbA1c≥6.3%,and 77.40%（181 subjects） had HbA1c≥6.5%.HbA1c≥6.3%combined FPG≥7.0 mmol/L increased the positive rate of newly diagnosed diabetes from 91.88%to 96.58%. Conclusions:HbA1c is a practical and convenient tool for screening undiagnosed diabetes in routine health check-up of a large population.Combined use of HbA1c≥6.3%and/or FPG≥7.0 mmol/L is efficient for early detection of diabetes.