Effects of 1,2,4,6-tetra-O-galloyl-p-D-glucose from P. emblica on HBsAg and HBeAg Secretion in HepG2.2.15 Cell Culture

A polyphenolic compound, 1,2,4,6-tetra-O-galloyl-β-D-glucose （1246TGG）, was isolated from the traditional Chinese medicine Phyllanthus emblica L. （Euphorbiaceae） and assayed for its potential as an anti-hepatitis B virus （HBV） agent. The cytotoxicity of 1246TGG on HepG2.2.15 as well as HepG2 cells w...

Full description

Saved in:
Bibliographic Details
Published inVirologica Sinica no. 5; pp. 375 - 380
Main Author Yang-fei XIANG Huai-qiang JU Shen LI Ying-jun ZHANG Chong-ren YANG Yi-fei WANG
Format Journal Article
LanguageEnglish
Published 2010
Subjects
HBeAg
HBsAg
余甘子
没食子
细胞培养
葡萄糖
Online AccessGet full text

Cover

More Information
Summary:A polyphenolic compound, 1,2,4,6-tetra-O-galloyl-β-D-glucose （1246TGG）, was isolated from the traditional Chinese medicine Phyllanthus emblica L. （Euphorbiaceae） and assayed for its potential as an anti-hepatitis B virus （HBV） agent. The cytotoxicity of 1246TGG on HepG2.2.15 as well as HepG2 cells was determined by observing cytopathic effects, and the effects of 1246TGG on secretion of HBsAg and HBeAg in HepG2.2.15 cells were assayed by enzyme immunoassay. Results indicates that treatment with 1246TGG （6.25 ~tg/mL, 3.13 ~tg/mL）, reduced both HBsAg and HBeAg levels in culture supernatant, yet the inhibitory effects tend to decline with the assay time. This study provides a basis for further investigation of the anti-HBV activity and possible mechanism of action of 1246TGG
Bibliography:Phyllanthus emblica
Antiviral agents
Q78
1,2,4,6-tetra-O-galloyl-13-D-glucose （1246TGG）; Phyllanthus emblica; Euphorbiaceae; HBV;Antiviral agents
1,2,4,6-tetra-O-galloyl-13-D-glucose （1246TGG）
42-1760/Q
Euphorbiaceae
TQ464.9
HBV
ISSN:1674-0769
1995-820X