Sodium tetrachloroaurate（Ⅲ） dihydrate-catalyzed efficient synthesis of 1,5-benzodiazepine and quinoxaline derivatives

Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocycles in pharmaceuticals. We describe an efficient and clean method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones catalyzed by sodium tetrachloroaurate（Ⅲ） dihydrate under mild conditions. The cata...

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Bibliographic Details
Published inJournal of Zhejiang University. B. Science no. 2; pp. 102 - 108
Main Author Ren-xin SHI Yun-kui LIU Zhen-yuan XU
Format Journal Article
LanguageEnglish
Published 2010
Subjects
催化合成
喹喔啉
有效合成
氯金酸
衍生物
邻苯二胺
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Summary:Both 1,5-benzodiazepine and quinoxaline derivatives are important heterocycles in pharmaceuticals. We describe an efficient and clean method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones catalyzed by sodium tetrachloroaurate（Ⅲ） dihydrate under mild conditions. The catalyst was shown to be equally effective for the synthesis of quinoxalines from o-phenylenediamine and α-bromo ketones under the similar reaction conditions. This method produced good yields.
Bibliography:TQ246.31
33-1356/Q
1,5-benzodiaepines, o-phenylenediamine, Ketones, Quinoxalines, Gold catalyst
O625.322
ISSN:1673-1581
1862-1783