Methylation Profile Difference in Human High- Metastatic Large Cell Lung Cancer Cell Lines with Different Metastatic Potential

• Published in: Zhongguo fei ai za zhi Vol. 12; no. 6; pp. 511 - 512
• Main Author: Hui LV Xiaoming QIU Ting WANG Yu FAN Li MA Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Qinghua ZHOU
• Format: Journal Article
• Language: Chinese
• Published: 2009
• Subjects: 化疗; 扩散; 癌细胞; 肺癌
• ISSN: 1009-3419; 1999-6187

Background and Objective Invasion and metastasis is one malignant phenotype of lung cancer and cause the death of lung cancer patients. Present evidence has proved that invasion and metastasis in lung cancer is a complicated course with multiple steps and stages and regulated both by metastasis suppressor genes and metastasis promoting genes. Therefore, it is very important to study and elucidate the molecular mechanism of invasion and metastasis in lung cancer. Nm23-H1 was originally identified as a tumor metastasis suppressor gene. The abnormality of its function and structure was closely correlated with the invasion and metastasis of cancer cells. Our previous research has proved that the reduced expression and hetero-deletion of nm23-H1 gene is closely correlated with the high metastasis potential of lung cancer and the key upstream gene of ＂metastasis suppress cascades＂. Although little is known about the exact anti-metastasis molecular mechanisms of nm23-H1. Resently,