The Effects of IntracelluIar Glutathione Content on the Sensitivity of Methylseleninic Acid to Human High-metastatic Large Cell Lung Cancer Cell Line L9981

Background and Objective Lung cancer has the fastest increasing rate of morbidity and mortality all over the world and appears to be one of the most dangerous malignant tumors that is threatening human being's health and lives, it also has the lowest cure rate on all tumors. Although operation is th...

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Published inZhongguo fei ai za zhi Vol. 12; no. 6; pp. 510 - 511
Main Author Chengfei LIU Jun CHEN Liya SUN Yu ZHU Ting WANG Na-galakshmi NADIMINTY Allen C. GAO Qinghua ZHOU
Format Journal Article
LanguageChinese
Published 2009
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Summary:Background and Objective Lung cancer has the fastest increasing rate of morbidity and mortality all over the world and appears to be one of the most dangerous malignant tumors that is threatening human being's health and lives, it also has the lowest cure rate on all tumors. Although operation is the first choice to the early stage lung cancer, but searching for new antilung cancer drugs, especially the one with maximal effiiency and minimal toxicities is necessary to cure the advanced lung cancer and prolong the patients' lives. Selenium has been well known as an antioxidant in the nutritional range of intake, in many human clinical trials. Supra-nutritional selenium supplement has been shown to reduce risk of cancers of several organs, including lung cancer, there still has several clinical ongoing trials to confirm the cancer chemopreventive effects of selenium.
Bibliography:Cellcycle
R734.2
ROS
Human high-metastatic large cell lung cancer lineL9981
Methylseleninic acid
12-1395/R
Methylseleninic acid; Glutathione; Apoptosis; Cellcycle; ROS; Human high-metastatic large cell lung cancer lineL9981
Glutathione
Apoptosis
ISSN:1009-3419
1999-6187