CD 13/APN expression in peripheral blood lymphocytes and skin lesions in patients with advanced psoriasis vulgaris

• Published in: Journal of Medical Colleges of PLA Vol. 24; no. 1; pp. 25 - 30
• Main Author: Liu Taihua Liu Defang Chen Yihua Hu Zonghai Chen Lu Luo Chen Xu Zhejuan
• Format: Journal Article
• Language: English
• Published: 2009
• Subjects: CD13; 伤患者; 健康对照组; 外周血淋巴细胞; 寻常型银屑病; 流式细胞仪检测; 皮肤组织; 角质形成细胞
• ISSN: 1000-1948

Objective： To observe the expression of CD13/APN in peripheral blood lymphocytes and skin lesions of patients with advanced psoriasis vulgaris, and discuss its effect on the pathogenesis of psoriasis. Methods： CD 13 expression in peripheral blood lymphocytes and skin lesions was detected by flow cytometry and imrnunohistochemical technique, respectively. Results were compared with those of healthy controls. Results： CD 13 expression was significantly higher in peripheral blood lymphocytes of patients with advanced psoriasis vulgaris than in that of healthy controls, and in skin lesions than in healthy skin tissues. The expression was mainly in the suprabasal layers of skin lesions, and positively correlated to PASI （R 0.78029）. Conclusion： The significantly higher expression of CD13 in peripheral blood lymphocytes and skin lesions of the patients with advanced psoriasis vulgaris probably is related to immunological abnormality, blood vessel abnormality and proliferation of keratinocyte in the pathogenic course of psoriasis. It may be a novel and effective way to treat psoriasis with specific CD13 inhibitors.