Anfitumor Activities of Apple Extracts

• Published in: Clinical oncology and cancer research Vol. 3; no. 1; pp. 37 - 40
• Main Author: Peng Zhao Yan Zhuang Jianzhong Liu Xishan Hao Ming Liu
• Format: Journal Article
• Language: English
• Published: 2006
• Subjects: 抗癌活性; 植物化学; 细胞凋亡
• ISSN: 1674-5361; 1868-324X

OBJECTIVE To examine the antitumor activities of fresh apple extracts. METHODS Fuji apple extracts were tested for their anti-LS-174T-proliferative activities, for their effect on expression of PCNA, and ability to induce apoptosis in a LS-174T cell line. RESULTS Apple extracts inhibited LS-174T cellular proliferation in a concentration and time dependent manner. The apple extracts equivalent to a concentration of 50 mg/ml inhibited the proliferation of the LS-174T cells by 34.5±1.2% after 48 h and 47.5±1.8% after 72 h respectively. Apple extracts inhibited PCNA expression and induced apoptosis of the LS-174T cells at concentrations above 12.5mg/ml. CONCLUSION Apple extracts can inhibit PCNA expression and induction of apoptosis in LS-174T cells which may contribute to their inhibitiory effect on cellular proliferation.