Cloning and expression of the fusion protein of interleukin-2 and ESAT6 in Mycobacterium bovis Bacillus Calmette Gurin strain

Tuberculosis (TB) is the most common cause of death in infectious diseases; it is estimated that approximately 2 million people per year die of TB. The present available TB vaccine is a live attenuated strain, Mycobacterium bovis Bacillus Calmette Guérin (BCG). However, it has been shown that BCG ha...

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Published inChinese medical journal Vol. 118; no. 9; pp. 762 - 765
Main Author FANXiong-lin WANGLi-mei LUXian-yu TUZhi-guang SHIChang-hong XUZhi-kai
Format Journal Article
LanguageEnglish
Published 2005
Subjects
ESAT6
分子克隆
分支杆菌
基因表达
溶解蛋白
白介素-2
细菌感染
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Abstract Tuberculosis (TB) is the most common cause of death in infectious diseases; it is estimated that approximately 2 million people per year die of TB. The present available TB vaccine is a live attenuated strain, Mycobacterium bovis Bacillus Calmette Guérin (BCG). However, it has been shown that BCG has variable protective efficacy, ranging from 0 to 85% in different clinical experiments. ^1Therefore, a new TB vaccine is urgently needed.
AbstractList Tuberculosis (TB) is the most common cause of death in infectious diseases; it is estimated that approximately 2 million people per year die of TB. The present available TB vaccine is a live attenuated strain, Mycobacterium bovis Bacillus Calmette Guérin (BCG). However, it has been shown that BCG has variable protective efficacy, ranging from 0 to 85% in different clinical experiments. ^1Therefore, a new TB vaccine is urgently needed.
Author FANXiong-lin WANGLi-mei LUXian-yu TUZhi-guang SHIChang-hong XUZhi-kai
AuthorAffiliation DepartmentofClinicalImmunology,ChongqingUniversityofMedicalScience,Chongqing400016,China DepartmentofMicrobiology,FourthMilitaryMedicalUniversity,Xi＇an710032,China DepartmentofPathogenicBiology,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,China
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SubjectTerms ESAT6
分子克隆
分支杆菌
基因表达
溶解蛋白
白介素-2
细菌感染
Title Cloning and expression of the fusion protein of interleukin-2 and ESAT6 in Mycobacterium bovis Bacillus Calmette Gurin strain
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