Cloning and expression of the fusion protein of interleukin-2 and ESAT6 in Mycobacterium bovis Bacillus Calmette Gurin strain

Tuberculosis (TB) is the most common cause of death in infectious diseases; it is estimated that approximately 2 million people per year die of TB. The present available TB vaccine is a live attenuated strain, Mycobacterium bovis Bacillus Calmette Guérin (BCG). However, it has been shown that BCG ha...

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Bibliographic Details
Published inChinese medical journal Vol. 118; no. 9; pp. 762 - 765
Main Author FANXiong-lin WANGLi-mei LUXian-yu TUZhi-guang SHIChang-hong XUZhi-kai
Format Journal Article
LanguageEnglish
Published 2005
Subjects
ESAT6
分子克隆
分支杆菌
基因表达
溶解蛋白
白介素-2
细菌感染
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Summary:Tuberculosis (TB) is the most common cause of death in infectious diseases; it is estimated that approximately 2 million people per year die of TB. The present available TB vaccine is a live attenuated strain, Mycobacterium bovis Bacillus Calmette Guérin (BCG). However, it has been shown that BCG has variable protective efficacy, ranging from 0 to 85% in different clinical experiments. ^1Therefore, a new TB vaccine is urgently needed.
Bibliography:R515
11-2154/R
ISSN:0366-6999
2542-5641